ABSTRACT
Peptic ulcer disease is a common condition of present day life, and its incidence is markedly increasing. The available drugs for the treatment are associated with adverse effects. Hence, there is a need for newer and better treatment for the same. Objectives: To evaluate the anti-ulcer activity of ethanolic extract of Vitis Vinifera (seed) by Water Immersion stress induced gastric ulcer model in Wistar albino rats using two doses (100, 200mg/kg body weight.) Methods: The antiulcer activity was assessed by estimating gastric volume, pH, free and total acidity; ulcer number and its inhibition, gastric lesion, ulcer severity and ulcer index; and comparing it with the control groups. Results: The present study revealed that grape seed extract of 100mg/kg and 200mg/kg showed a significant (p<0.05) reduction in the gastric volume, ulcer number, gastric lesion and severity. The ulcer index was 45.33 and 36.66 for 100 and 200mg/kg respectively. Ulcer inhibition for 100 and 200 mg/kg group was 32.79% and 44.86% when compared with the control group. Ulcer protection with 100 and 200mg/kg was 29.21% and 39.82% when compared with the control group. Conclusion: This present study indicates that Vitis vinifera seed extract have potential anti-ulcer activity in the model tested.